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https://hdl.handle.net/10216/119040| Author(s): | Gomes, J Mereiter, S Magalhães, A Reis, CA |
| Title: | Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries |
| Publisher: | Elsevier (Cell Press) |
| Issue Date: | 2017 |
| Abstract: | Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. |
| URI: | https://hdl.handle.net/10216/119040 |
| Source: | Cancer Cell, vol.32(5), p. 544-545 |
| Related Information: | info:eu-repo/grantAgreement/FCT/5876/147342/PT |
| Document Type: | Outra Publicação em Revista Científica Internacional |
| Rights: | openAccess |
| License: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Appears in Collections: | I3S - Outra Publicação em Revista Científica Internacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| i3s_Gomes et al_Cancer Cell_2017.pdf | 329.44 kB | Adobe PDF |  View/Open |
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