Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/119040
Author(s): Gomes, J
Mereiter, S
Magalhães, A
Reis, CA
Title: Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries
Publisher: Elsevier (Cell Press)
Issue Date: 2017
Abstract: Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
URI: https://hdl.handle.net/10216/119040
Source: Cancer Cell, vol.32(5), p. 544-545
Related Information: info:eu-repo/grantAgreement/FCT/5876/147342/PT
Document Type: Outra Publicação em Revista Científica Internacional
Rights: openAccess
License: http://creativecommons.org/licenses/by-nc-nd/4.0/
Appears in Collections:I3S - Outra Publicação em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
i3s_Gomes et al_Cancer Cell_2017.pdf329.44 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons