1. Repositório Aberto da Universidade do Porto
  2. I3S - Instituto de Investigação e Inovação em Saúde
  3. I3S - Outra Publicação em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/119040
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dc.creatorGomes, J
dc.creatorMereiter, S
dc.creatorMagalhães, A
dc.creatorReis, CA
dc.date.accessioned2019-02-21T12:16:20Z-
dc.date.available2019-02-21T12:16:20Z-
dc.date.issued2017
dc.identifier.issn1535-6108
dc.identifier.urihttps://hdl.handle.net/10216/119040-
dc.description.abstractGlycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14. Glycosylation alterations are frequently observed in cancer cells and shape tumor progression. In this issue of Cancer Cell, Nguyen et al. show that GALNT1 relocation from Golgi to endoplasmic reticulum drives liver tumor growth and invasion, due to enhanced glycosylation and consequential activation of the extracellular matrix-degrading metalloproteinase MMP14.
dc.description.sponsorshipThe authors acknowledge funding by FEDER, COMPETE, and FCT: POCI-01-0145-FEDER-007274 (UID/BIM/04293/2013), POCI-01-0145-FEDER-016585 (PTDC/BBB-EBI/0567/2014),NORTE 2020 (NORTE-01-0145-FEDER-000029); and EU 7th framework programme ITN 316929.
dc.language.isoeng
dc.publisherElsevier (Cell Press)
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147342/PT
dc.relation.ispartofCancer Cell, vol.32(5), p. 544-545
dc.rightsopenAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleEarly GalNAc O-Glycosylation: Pushing the Tumor Boundaries
dc.typeOutra Publicação em Revista Científica Internacional
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde
dc.identifier.doi10.1016/j.ccell.2017.10.010
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1535610817304634?via%3Dihub
Appears in Collections:I3S - Outra Publicação em Revista Científica Internacional

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