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Author(s): Carvalho, S
Reis, CA
Pinho, SS
Title: Cadherins Glycans in Cancer: Sweet Players in a Bitter Process
Publisher: Cell Press
Issue Date: 2016
Abstract: Cadherins are key components in tissue morphogenesis and architecture, contributing to the establishment of cohesive cell adhesion. Reduced cellular adhesiveness as a result of cadherin dysfunction is a defining feature of cancer. During tumor development and progression, major changes in the glycan repertoire of cancer cells take place, affecting the stability, trafficking, and cell-adhesion properties of cadherins. Importantly, the different glycoforms of cadherins are promising biomarkers, with potential clinical application to improve the management of patients, and constitute targets for the development of new therapies. This review discusses the most recent insights on the impact of glycan structure on the regulation of cadherin function in cancer, and provides a perspective on how cadherin glycans constitute tumor biomarkers and potential therapeutic targets.
Subject: Animals
Biomarkers, Tumor/metabolism
Cell Adhesion
Source: Trends in Cancer, vol.2(9), p. 519-531
Related Information: info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F77386%2F2011/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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