Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/118208
Author(s): | Pinho, SS Reis, CA |
Title: | Glycosylation in cancer: Mechanisms and clinical implications |
Publisher: | Nature Publishing Group |
Issue Date: | 2015 |
Abstract: | Despite recent progress in understanding the cancer genome, there is still a relative delay in understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology has been instrumental in relevant discoveries in various biological and medical fields, and has contributed to the deciphering of several human diseases. Glycans are involved in fundamental molecular and cell biology processes occurring in cancer, such as cell signalling and communication, tumour cell dissociation and invasion, cell-matrix interactions, tumour angiogenesis, immune modulation and metastasis formation. The roles of glycans in cancer have been highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention. This Review discusses the role of glycans in fundamental mechanisms controlling cancer development and progression, and their applications in oncology. |
Subject: | Glycoconjugates/metabolism Glycosylation Humans Neoplasms/diagnosis Neoplasms/immunology Neoplasms/metabolism Neoplasms/pathology Neoplasms/therapy Polysaccharides/immunology Polysaccharides/metabolism |
URI: | https://repositorio-aberto.up.pt/handle/10216/118208 |
Source: | Nature Reviews Cancer, vol.15(9), p. 540-555 |
Related Information: | info:eu-repo/grantAgreement/FCT/COMPETE/132983/PT info:eu-repo/grantAgreement/FCT/COMPETE/125428/PT info:eu-repo/grantAgreement/FCT/5876-PPCDTI/124445/PT info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F63094% |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Glycosylation in cancer mechanisms and clinical implications.pdf | 1 MB | Adobe PDF | View/Open |
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