Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/118189
Author(s): Cecílio, P
Pérez-Cabezas, B
Santarém, N
Maciel, J
Rodrigues, V
Cordeiro-da-Silva, A
Title: Deception and manipulation: The arms of Leishmania, a successful parasite
Publisher: Frontiers Media
Issue Date: 2014
Abstract: Leishmania spp. are intracellular parasitic protozoa responsible for a group of neglected tropical diseases, endemic in 98 countries around the world, called leishmaniasis. These parasites have a complex digenetic life cycle requiring a susceptible vertebrate host and a permissive insect vector, which allow their transmission. The clinical manifestations associated with leishmaniasis depend on complex interactions between the parasite and the host immune system. Consequently, leishmaniasis can be manifested as a self-healing cutaneous affliction or a visceral pathology, being the last one fatal in 85-90% of untreated cases. As a result of a long host-parasite co-evolutionary process, Leishmania spp. developed different immunomodulatory strategies that are essential for the establishment of infection. Only through deception and manipulation of the immune system, Leishmania spp. can complete its life cycle and survive. The understanding of the mechanisms associated with immune evasion and disease progression is essential for the development of novel therapies and vaccine approaches. Here, we revise how the parasite manipulates cell death and immune responses to survive and thrive in the shadow of the immune system.
Subject: Leishmania
Acquired Immunity
Apoptosis
Immunomodulation
Innate Immunity
URI: https://repositorio-aberto.up.pt/handle/10216/118189
Source: Frontiers in Immunology, vol.5: 480
Related Information: info:eu-repo/grantAgreement/FCT/COMPETE/118644/PT
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F64064%2F2009/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
Cecilio_Frontiers in Immunology_2014.pdf702.11 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.