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Author(s): Pérez-Cabezas, B
Cecílio, P
Robalo, AL
Silvestre, R
Carrillo, E
Moreno, J
San, Martín J
Vasconcellos, R
Cordeiro-da-Silva, A
Title: Interleukin-27 early impacts Leishmania infantum infection in mice and correlates with active visceral disease in humans
Publisher: Frontiers Media
Issue Date: 2016
Abstract: The complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BL/6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens. Neutralization of IL-27 in acutely infected BALB/c led to decreased parasite burdens and a transient increase in IFN-¿ + splenic T cells, while administration of IL-27 to C57BL/6 promoted a local anti-inflammatory cytokine response at the site of infection and increased parasite loads. Overall, we show that, as in humans, BALB/c IL-27 systemic levels are infection dependently upregulated and may favor parasite installation by controlling inflammation.
Subject: IL-27
Leishmania Infantum
Immune Regulation
Mouse Models
Source: Frontiers in Immunology, vol.7: 478
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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