Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/118187
Author(s): | Pérez-Cabezas, B Cecílio, P Robalo, AL Silvestre, R Carrillo, E Moreno, J San, Martín J Vasconcellos, R Cordeiro-da-Silva, A |
Title: | Interleukin-27 early impacts Leishmania infantum infection in mice and correlates with active visceral disease in humans |
Publisher: | Frontiers Media |
Issue Date: | 2016 |
Abstract: | The complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, suggesting this cytokine as a probable infection mediator. We further addressed this hypothesis recurring to two classical susceptible visceral leishmaniasis mouse models. BALB/c, but not C57BL/6 mice, showed increased IL-27 systemic levels after infection, which was associated with an upregulation of IL-27p28 expression by dendritic cells and higher parasite burdens. Neutralization of IL-27 in acutely infected BALB/c led to decreased parasite burdens and a transient increase in IFN-¿ + splenic T cells, while administration of IL-27 to C57BL/6 promoted a local anti-inflammatory cytokine response at the site of infection and increased parasite loads. Overall, we show that, as in humans, BALB/c IL-27 systemic levels are infection dependently upregulated and may favor parasite installation by controlling inflammation. |
Subject: | IL-27 Leishmania Infantum Human Immune Regulation Mouse Models |
URI: | https://repositorio-aberto.up.pt/handle/10216/118187 |
Source: | Frontiers in Immunology, vol.7: 478 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Begona_IL27_Front Immunol_2016.pdf | 3.98 MB | Adobe PDF | View/Open |
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