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Author(s): Marta Ribeiro
Joana Malheiro
Liliana Grenho
Maria Helena Fernandes
Manuel Simões
Title: Cytotoxicity and antimicrobial action of selected phytochemicals against planktonic and sessile Streptococcus mutans
Issue Date: 2018
Abstract: Dental caries remains the most prevalent and costly oral infectiousdisease worldwide, encouraging the search for new and more effective antimicrobials.Therefore, the aim of this work was to study the antimicrobial action of selected phytochemicals (eugenol, citronellol, sabinene hydrate, trans-cinnamaldehyde, terpineol andcinnamic acid) against Streptococcus mutans in planktonic and biofilm states as well asthe cytotoxicity of these compounds.Methods. The antibacterial activity of the selected compounds was evaluated by thedetermination of the minimal bactericidal concentration. The resazurin assay was usedto assess the metabolic activity of sessile S. mutans. The cytotoxicity was determinedusing a fibroblast cell line.Results. Among the tested phytochemicals, citronellol, cinnamic acid and transcinnamaldehyde were the most effective against both planktonic and sessile S. mutans,an effect apparently related to their hydrophobic character. Additionally, these threecompounds did not compromise fibroblasts cell viability.Discussion. Citronellol, cinnamic acid and trans-cinnamaldehyde demonstrated significant antimicrobial activity and low cytotoxicity proposing their potential as a novelgroup of therapeutic compounds to control oral infectious diseases. Moreover, theireffects are particularly relevant when benchmarked against eugenol, a phytochemicalcommonly used for prosthodontic applications in dentistry.
Subject: Ciências da Saúde, Ciências médicas e da saúde
Health sciences, Medical and Health sciences
Scientific areas: Ciências médicas e da saúde
Medical and Health sciences
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/UID/EQU/00511/2013 - POCI-01-0145-FEDER-006939/Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia/LEPABE
info:eu-repo/grantAgreement/Comissão de Coordenação e Desenvolvimento Regional do Norte/P2020|Norte2020-Projetos Integrados ICDT/NORTE-01-0145-FEDER-000005/LEPABE-2-ECO-INNOVATION/LEPABE-2-ECO-INNOVATION
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional
FMDUP - Artigo em Revista Científica Internacional

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