Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/111524
Author(s): | França, M Alberich-Bayarri, Á Martí-Bonmatí, L Oliveira, P Costa, FE Porto, G Vizcaíno, JR Gonzalez, JS Ribeiro, E Oliveira, J Miranda, HP |
Title: | Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI |
Publisher: | Springer US |
Issue Date: | 2017 |
Abstract: | Purpose: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload in a wide spectrum of diffuse liver diseases having biopsy as reference standard. Methods: MECSE-MR-acquired images were used to calculate fat fraction and iron content in a single breath-hold in 109 adult patients. Proton density fat fraction (PDFF) was prospectively estimated using complex-based data reconstruction with multipeak fat modeling. Water R2* was used to estimate iron content. Biopsy was obtained in all cases, grading liver steatosis, siderosis, inflammation, and fibrosis. Differences in PDFF and R2* values across histopathological grades were analyzed, and ROC curves analyses evaluated the MR diagnostic performance. Results: Calculated fat fraction measurements showed significant differences (p < 0.001) among steatosis grades, being unaffected by the presence of inflammation or fibrosis (p ≥ 0.05). A strong correlation was found between fat fraction and steatosis grade (R S = 0.718, p < 0.001). Iron deposits did not affect fat fraction quantitation (p ≥ 0.05), except in cases with severe iron overload (grade 4). A strong positive correlation was also observed between R2* measurements and iron grades (R S = 0.704, p < 0.001). Calculated R2* values were not different across grades of steatosis, inflammation, and fibrosis (p ≥ 0.05). Conclusion: A MECSE-MR sequence simultaneously quantifies liver steatosis and siderosis, regardless coexisting liver inflammation or fibrosis, with high accuracy in a wide spectrum of diffuse liver disorders. This sequence can be acquired within a single breath-hold and can be implemented in the routine MR evaluation of the liver. |
Subject: | Fat quantification Iron overload R2* measurement Chronic liver diseases Quantitative imaging biomarkers |
URI: | http://hdl.handle.net/10216/111524 |
Source: | Abdom Radiol, vol. 42(5), p. 1434-1443 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | ISPUP - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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Franca425.pdf | 2.82 MB | Adobe PDF | View/Open |
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