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dc.creatorFrança, M-
dc.creatorAlberich-Bayarri, Á-
dc.creatorMartí-Bonmatí, L-
dc.creatorOliveira, P-
dc.creatorCosta, FE-
dc.creatorPorto, G-
dc.creatorVizcaíno, JR-
dc.creatorGonzalez, JS-
dc.creatorRibeiro, E-
dc.creatorOliveira, J-
dc.creatorMiranda, HP-
dc.description.abstractPurpose: To evaluate the diagnostic performances of 3 Tesla multi-echo chemical shift-encoded gradient echo magnetic resonance (MECSE-MR) imaging to simultaneously quantify liver steatosis and iron overload in a wide spectrum of diffuse liver diseases having biopsy as reference standard. Methods: MECSE-MR-acquired images were used to calculate fat fraction and iron content in a single breath-hold in 109 adult patients. Proton density fat fraction (PDFF) was prospectively estimated using complex-based data reconstruction with multipeak fat modeling. Water R2* was used to estimate iron content. Biopsy was obtained in all cases, grading liver steatosis, siderosis, inflammation, and fibrosis. Differences in PDFF and R2* values across histopathological grades were analyzed, and ROC curves analyses evaluated the MR diagnostic performance. Results: Calculated fat fraction measurements showed significant differences (p < 0.001) among steatosis grades, being unaffected by the presence of inflammation or fibrosis (p ≥ 0.05). A strong correlation was found between fat fraction and steatosis grade (R S = 0.718, p < 0.001). Iron deposits did not affect fat fraction quantitation (p ≥ 0.05), except in cases with severe iron overload (grade 4). A strong positive correlation was also observed between R2* measurements and iron grades (R S = 0.704, p < 0.001). Calculated R2* values were not different across grades of steatosis, inflammation, and fibrosis (p ≥ 0.05). Conclusion: A MECSE-MR sequence simultaneously quantifies liver steatosis and siderosis, regardless coexisting liver inflammation or fibrosis, with high accuracy in a wide spectrum of diffuse liver disorders. This sequence can be acquired within a single breath-hold and can be implemented in the routine MR evaluation of the liver.-
dc.description.sponsorshipThis work was partially funded by a research grant from the Teaching and Research Department of Centro Hospitalar do Porto (DEFI:309/12(213-DEFI/251-CES)) and from a Spanish Ministry of Health and Carlos III Health Institute funding grant (PI12/01262). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.-
dc.publisherSpringer US-
dc.relation.ispartofAbdom Radiol, vol. 42(5), p. 1434-1443-
dc.subjectFat quantification-
dc.subjectIron overload-
dc.subjectR2* measurement-
dc.subjectChronic liver diseases-
dc.subjectQuantitative imaging biomarkers-
dc.titleAccurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI-
dc.typeArtigo em Revista Científica Internacional-
dc.contributor.uportoInstituto de Saúde Pública-
Appears in Collections:ISPUP - Artigo em Revista Científica Internacional

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