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Author(s): Thieleke-Matos, C
Osório, DS
Carvalho, AX
Morais-de-Sá, E
Title: Emerging Mechanisms and Roles for Asymmetric Cytokinesis
Publisher: Elsevier
Issue Date: 2017
Abstract: Cytokinesis completes cell division by physically separating the contents of the mother cell between the two daughter cells. This event requires the highly coordinated reorganization of the cytoskeleton within a precise window of time to ensure faithful genomic segregation. In addition, recent progress in the field highlighted the importance of cytokinesis in providing particularly important cues in the context of multicellular tissues. The organization of the cytokinetic machinery and the asymmetric localization or inheritance of the midbody remnants is critical to define the spatial distribution of mechanical and biochemical signals. After a brief overview of the conserved steps of animal cytokinesis, we review the mechanisms controlling polarized cytokinesis focusing on the challenges of epithelial cytokinesis. Finally, we discuss the significance of these asymmetries in defining embryonic body axes, determining cell fate, and ensuring the correct propagation of epithelial organization during proliferation.
Subject: Animals
Asymmetric cell division
Body patterning
Cell shape
Models, Biological
Series: International review of cell and molecular biology, vol. 332, p. 297-345
Related Information: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/120132/PT
Document Type: Capítulo ou Parte de Livro
Rights: restrictedAccess
Appears in Collections:I3S - Capítulo ou Parte de Livro

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