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dc.creatorThieleke-Matos, C-
dc.creatorOsório, DS-
dc.creatorCarvalho, AX-
dc.creatorMorais-de-Sá, E-
dc.description.abstractCytokinesis completes cell division by physically separating the contents of the mother cell between the two daughter cells. This event requires the highly coordinated reorganization of the cytoskeleton within a precise window of time to ensure faithful genomic segregation. In addition, recent progress in the field highlighted the importance of cytokinesis in providing particularly important cues in the context of multicellular tissues. The organization of the cytokinetic machinery and the asymmetric localization or inheritance of the midbody remnants is critical to define the spatial distribution of mechanical and biochemical signals. After a brief overview of the conserved steps of animal cytokinesis, we review the mechanisms controlling polarized cytokinesis focusing on the challenges of epithelial cytokinesis. Finally, we discuss the significance of these asymmetries in defining embryonic body axes, determining cell fate, and ensuring the correct propagation of epithelial organization during proliferation.pt_PT
dc.description.sponsorshipThis work was supported by grants from FCT (Fund ação para a Ciência e a Tecnologia) under projects (PTDC/BIA - BCM/120132/2010) and (PTDC/BEX - BCM/0432/2014) to E.M. and from the European Research Council to AXC (grant 640553). AXC and EM have FCT Investigator positions funded by FCT and co - funded by ESF t hrough POPH Type 4.2 - Promotion of Scientific Employment.-
dc.relation.ispartofseriesInternational review of cell and molecular biology, vol. 332, p. 297-345pt_PT
dc.subjectAsymmetric cell divisionpt_PT
dc.subjectBody patterningpt_PT
dc.subjectCell shapept_PT
dc.subjectModels, Biologicalpt_PT
dc.titleEmerging Mechanisms and Roles for Asymmetric Cytokinesispt_PT
dc.typeCapítulo ou Parte de Livropt_PT
dc.contributor.uportoInstituto de Investigação e Inovação em Saúdept_PT
Appears in Collections:I3S - Capítulo ou Parte de Livro

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