Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/110107
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dc.creatorMerigo, L
dc.creatorPadula, F
dc.creatorLatronico, N
dc.creatorMendonca, T
dc.creatorPaltenghi, M
dc.creatorRocha, P
dc.creatorVisioli, A
dc.date.accessioned2019-02-03T04:34:40Z-
dc.date.available2019-02-03T04:34:40Z-
dc.date.issued2017
dc.identifier.issn2405-8963
dc.identifier.othersigarra:218850
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/110107-
dc.description.abstractIn this paper we analyse the use of different models to describe the effects of propofol in the induction of hypnosis on a patient during surgery. In particular, we consider the standard three-compartmental pharmacokinetics/pharmacodynamics Wiener model and a suitable reduction of it. The estimation of the parameters is based on real bispectral index scale surgical data and it is performed by using genetic algorithms. The results obtained for different patients show that the standard model fits the data better than the reduced model, but it is overparameterized and its structure is much more complex to be used for the control design. Conversely, the simplification of the identification procedure obtained with the reduced model, which has only three parameters, is paid by only a slight decrement of the performance.
dc.language.isoeng
dc.relation.ispartofIFAC PAPERSONLINE
dc.rightsopenAccess
dc.titleOn the Identification of the Propofol PK/PD Model Using BIS Measurements
dc.typeArtigo em Livro de Atas de Conferência Internacional
dc.contributor.uportoFaculdade de Engenharia
dc.contributor.uportoFaculdade de Ciências
dc.identifier.doi10.1016/j.ifacol.2017.08.261
dc.identifier.authenticusP-00N-4D8
Appears in Collections:FCUP - Artigo em Livro de Atas de Conferência Internacional
FEUP - Artigo em Livro de Atas de Conferência Internacional

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