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Author(s): Pereira, L
Gusmão, L
Prata, MJ
Mota, P
Trovoada, MJ
Amorim, A
Title: Variation in STR loci of the human myelin basic protein gene: North Portugal and São Tomé e Príncipe
Publisher: Wayne State University Press
Issue Date: 2000
Abstract: Allele frequencies and a single-base substitution polymorphism for 3 short tandem repeat (STR) loci of the human myelin basic protein (MBP) gene were evaluated in North Portugal and São Tomé e Príncipe. Strong linkage disequilibrium between loci MBPB and MBPC was found. However, the patterns of nonrandom allelic associations were very different in the 2 populations: levels of haplotypic diversity and heterozygosity were higher in the São Tomé population. Similarly, a difference in the frequency of base substitution G-->A at position 124 was found: the frequency reached 4.1% in North Portugal and 0.5% in São Tomé. In both populations it was always found to be associated with haplotypes B10/C11 and B12/C9.
Subject: MBP
linkage disequilibrium
single-nucleotide substitution
population genetics
Source: Human Biology, vol. 72(3), p. 481-7
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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