Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/109272
Author(s): | Pereira, L Gusmão, L Prata, MJ Mota, P Trovoada, MJ Amorim, A |
Title: | Variation in STR loci of the human myelin basic protein gene: North Portugal and São Tomé e Príncipe |
Publisher: | Wayne State University Press |
Issue Date: | 2000 |
Abstract: | Allele frequencies and a single-base substitution polymorphism for 3 short tandem repeat (STR) loci of the human myelin basic protein (MBP) gene were evaluated in North Portugal and São Tomé e Príncipe. Strong linkage disequilibrium between loci MBPB and MBPC was found. However, the patterns of nonrandom allelic associations were very different in the 2 populations: levels of haplotypic diversity and heterozygosity were higher in the São Tomé population. Similarly, a difference in the frequency of base substitution G-->A at position 124 was found: the frequency reached 4.1% in North Portugal and 0.5% in São Tomé. In both populations it was always found to be associated with haplotypes B10/C11 and B12/C9. |
Subject: | MBP linkage disequilibrium single-nucleotide substitution Population Genetics |
URI: | http://hdl.handle.net/10216/109272 |
Source: | Human Biology, vol. 72(3), p. 481-7 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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PereiraHumBiol2000b.pdf | 590.74 kB | Adobe PDF | View/Open |
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