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https://hdl.handle.net/10216/109272
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DC Field | Value | Language |
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dc.creator | Pereira, L | - |
dc.creator | Gusmão, L | - |
dc.creator | Prata, MJ | - |
dc.creator | Mota, P | - |
dc.creator | Trovoada, MJ | - |
dc.creator | Amorim, A | - |
dc.date.accessioned | 2017-12-18T14:31:55Z | - |
dc.date.available | 2017-12-18T14:31:55Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0018-7143 | - |
dc.identifier.uri | http://hdl.handle.net/10216/109272 | - |
dc.description.abstract | Allele frequencies and a single-base substitution polymorphism for 3 short tandem repeat (STR) loci of the human myelin basic protein (MBP) gene were evaluated in North Portugal and São Tomé e Príncipe. Strong linkage disequilibrium between loci MBPB and MBPC was found. However, the patterns of nonrandom allelic associations were very different in the 2 populations: levels of haplotypic diversity and heterozygosity were higher in the São Tomé population. Similarly, a difference in the frequency of base substitution G-->A at position 124 was found: the frequency reached 4.1% in North Portugal and 0.5% in São Tomé. In both populations it was always found to be associated with haplotypes B10/C11 and B12/C9. | - |
dc.description.sponsorship | This work was partially supported by Programa PRAXIS XXI through project PRAXIS/2/2.1/BIA/196/94, and Junta Nacional de Investigacao Cientifica e Tecnologica through grant BM/6723/95 | - |
dc.language.iso | eng | - |
dc.publisher | Wayne State University Press | - |
dc.relation.ispartof | Human Biology, vol. 72(3), p. 481-7 | - |
dc.rights | openAccess | - |
dc.subject | MBP | - |
dc.subject | linkage disequilibrium | - |
dc.subject | single-nucleotide substitution | - |
dc.subject | Population Genetics | - |
dc.title | Variation in STR loci of the human myelin basic protein gene: North Portugal and São Tomé e Príncipe | - |
dc.type | Artigo em Revista Científica Internacional | - |
dc.contributor.uporto | Instituto de Investigação e Inovação em Saúde | - |
dc.relation.publisherversion | https://www.jstor.org/stable/41465845 | - |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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PereiraHumBiol2000b.pdf | 590.74 kB | Adobe PDF | View/Open |
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