PET-MRI in Neuroimaging: technique role in Alzheimer Disease

Abstract

- Hybrid or multimodal imaging has provided excellent opportunities to meet the needs inherent in the management of neurodegenerative diseases, especially in Alzheimer Disease context. PET-MRI equipment for simultaneous data acquisition attempts to address this challenge by bridging the limitations of PET-CT at the brain level and improving the results achieved through a simultaneous real-time combination of quantitative neurophysiological information from PET and accurate MRI morphological information, with greater radiological safety. Therefore, the PET-MRI technique presents high potential for diagnostic and follow-up studies. The aim of this review was to compile the main advantages related with PET-MRI along with the detection of the main challenges which remain to be resolved for a full clinical validation of the technique in Neuroimaging field are identified.