PET-MRI in Neuroimaging: technique role in Alzheimer Disease

Abstract

- Hybrid or multimodal imaging has providedexcellent opportunities to meet the needs inherent in themanagement of neurodegenerative diseases, especially inAlzheimer Disease context. PET-MRI equipment forsimultaneous data acquisition attempts to address thischallenge by bridging the limitations of PET-CT at thebrain level and improving the results achieved through asimultaneous real-time combination of quantitativeneurophysiological information from PET and accurateMRI morphological information, with greaterradiological safety. Therefore, the PET-MRI techniquepresents high potential for diagnostic and follow-upstudies. The aim of this review was to compile the mainadvantages related with PET-MRI along with thedetection of the main challenges which remain to beresolved for a full clinical validation of the technique inNeuroimaging field are identified.