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Author(s): Rui Oliveira
Marta Susana Santos
Irina Amorim
Célia Lopes
Patricia Dias Pereira
Augusto Faustino
Title: An Immunohistochemical Study of Feline Endometrial Adenocarcinoma
Issue Date: 2009
Abstract: Feline endometrial adenocarcinomas are Uncommon malignant neoplasms that have to date been poorly characterized. The present immunohistochemical study describes the expression of the pancytokeratins AE1 and AE3, cytokeratin-14. vimentin, alpha-actin, cyclo-oxygenase-2, E-cadherin, beta-catenin, the progesterone receptor, the oestrogen receptor and caveolin-1 within normal feline uterine tissue and tissue from six cats with endometrial adenocarcinoma. Synthesis of cyclo-oxygenase-2 and reduced expression of progesterone receptors may be involved in the neoplastic transformation of feline endometrium. The loss Of Cellular adhesion that occurs within these tumours does not require down-regulation of E-cadherin expression and nuclear translocation of beta-catenin is not a feature of these neoplasms.
Subject: Ciências veterinárias
Veterinary science
Scientific areas: Ciências agrárias::Ciências veterinárias
Agrarian Sciences::Veterinary science
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

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