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Author(s): M. J. Ramalho
J. A. Loureiro
B. Gomes
M. F. Frasco
M. A. N. Coelho
M. C. Pereira
Title: PLGA nanoparticles for calcitriol delivery
Issue Date: 2015
Abstract: Calcitriol, the active metabolite of Vitamin D-3, is a potential anticancer agent but exhibits several drawbacks. Therefore, new therapeutic strategies, as specific drug delivery systems, must be developed in order to overcome those limitations. The aim of this work was to prepare poly(lactide-coglycolide) nanoparticles as drug delivery vehicles for calcitriol. Two formulation parameters, vitamin/polymer ratio and sonication time, were firstly studied and discussed using cholecalciferol as a drug model. Then, calcitriol-loaded poly(lactide-coglycolide) nanoparticles with controlled sizes and properties were prepared. The nanoparticles remained stable at storage conditions for several weeks and they were successfully lyophilized to increase their shelf-life using a crioprotectant. In vitro studies using two human cancer cell lines, S2-013 and A549, demonstrated that bare PLGA NPs are biocompatible.
Source: Proceedings - 2015 IEEE 4th Portuguese Meeting on Bioengineering, ENBENG 2015
Document Type: Artigo em Livro de Atas de Conferência Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Livro de Atas de Conferência Internacional

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