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Author(s): Vera Homem
Arminda Alves
Lúcia Santos
Title: Development and validation of a fast procedure to analyze amoxicillin in river waters by direct-injection LC-MS/MS
Issue Date: 2014
Abstract: A laboratory application with a strong component in analytical chemistry was designed for undergraduate students, in order to introduce a current problem in the environmental science field, the water contamination by antibiotics. Therefore, a simple and rapid method based on direct injection and high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and optimized for the determination of amoxicillin in river water. Students learned the main optimization steps for the improvement of the LC-MS/MS methodology and the correct procedure to validate an analytical method (draw a calibration curve, determine detection and quantification limits, precision, and accuracy). This laboratory experiment was successfully applied by students and enables the analysis of a large number of samples in a short period of time because of the short run time (3 min).
Subject: Engenharia do ambiente
Environmental engineering
Scientific areas: Ciências da engenharia e tecnologias::Engenharia do ambiente
Engineering and technology::Environmental engineering
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e Tecnologia/Projetos Estratégicos/PEst-C/EQB/UI0511/2013/PROJECTO ESTRATÉGICO - UI 511 - 2013-2014/UI0511
info:eu-repo/grantAgreement/Autoriadade de Gestão do Programa Operacional Regional do Norte/Programas Integrados de IC&DT/NORTE-07-0124-FEDER-000025/(Bio) Chemical Engineering: Multi-Scale Approaches for Sustainable Environment and Health/LEPAE/CEFT - RL2
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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