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Author(s): Maria do Rosário de Pinho
Maria Margarida Ferreira
Urszula Ledzewicz
Heinz Schaettler
Title: A model for cancer chemotherapy with state-space constraints
Issue Date: 2005
Abstract: The analysis of optimal control problems is significantly more difficult when state space constraints are imposed and thus in many modelling approaches explicit constraints are handled by including penalty terms in the objective. In this paper, we use the example of a simple model for cancer chemotherapy to compare the structure of extremals when upper limits on the total number of cancer cells are imposed (a) implicitly through a penalty term in the objective and (b) explicitly in the form of state-space constraints.
Subject: Engenharia de controlo, Matemática
Control engineering, Mathematics
Scientific areas: Ciências exactas e naturais::Matemática
Natural sciences::Mathematics
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FEUP - Artigo em Revista Científica Internacional

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