Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/101866
Full metadata record
DC Field | Value | Language |
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dc.creator | Manuela Florido | |
dc.creator | Shaun R McColl | |
dc.creator | Rui Appelberg | |
dc.date.accessioned | 2019-02-07T19:32:24Z | - |
dc.date.available | 2019-02-07T19:32:24Z | - |
dc.date.issued | 2009 | |
dc.identifier.issn | 0171-2985 | |
dc.identifier.other | sigarra:88287 | |
dc.identifier.uri | https://repositorio-aberto.up.pt/handle/10216/101866 | - |
dc.description.abstract | CD30 is a member of the tumor necrosis factor-receptor superfamily, a group of receptors known to act as accessory molecules in the development of the immune response. Control and CD30-deficient mice were aerogenically infected with Mycobacterium avium. Although the mycobacterial loads in the lungs were similar in both strains of mice, CD30-deficient animals exhibited delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes throughout a 240 days period of infection. Discrete alterations in the chemokine network were detected in the CD30-deficient animals although they showed no clear relation to the deficient inflammatory response. Thus CD30/CD 153 interactions are involved in lung immune-mediated inflammation. | |
dc.language.iso | eng | |
dc.rights | restrictedAccess | |
dc.subject | Infecções, Medicina básica | |
dc.subject | Infections, Basic medicine | |
dc.title | Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections | |
dc.type | Artigo em Revista Científica Internacional | |
dc.contributor.uporto | Instituto de Ciências Biomédicas Abel Salazar | |
dc.identifier.doi | 10.1016/j.imbio.2008.12.002 | |
dc.identifier.authenticus | P-00H-APD | |
dc.subject.fos | Ciências médicas e da saúde::Medicina básica | |
dc.subject.fos | Medical and Health sciences::Basic medicine | |
Appears in Collections: | ICBAS - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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88287.pdf Restricted Access | 737.9 kB | Adobe PDF | Request a copy from the Author(s) |
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