Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/101866
Author(s): | Manuela Florido Shaun R McColl Rui Appelberg |
Title: | Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections |
Issue Date: | 2009 |
Abstract: | CD30 is a member of the tumor necrosis factor-receptor superfamily, a group of receptors known to act as accessory molecules in the development of the immune response. Control and CD30-deficient mice were aerogenically infected with Mycobacterium avium. Although the mycobacterial loads in the lungs were similar in both strains of mice, CD30-deficient animals exhibited delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes throughout a 240 days period of infection. Discrete alterations in the chemokine network were detected in the CD30-deficient animals although they showed no clear relation to the deficient inflammatory response. Thus CD30/CD 153 interactions are involved in lung immune-mediated inflammation. |
Subject: | Infecções, Medicina básica Infections, Basic medicine |
Scientific areas: | Ciências médicas e da saúde::Medicina básica Medical and Health sciences::Basic medicine |
URI: | https://repositorio-aberto.up.pt/handle/10216/101866 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | ICBAS - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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88287.pdf Restricted Access | 737.9 kB | Adobe PDF | Request a copy from the Author(s) |
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