Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/93472
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dc.creatorClaudia Nobrega
dc.creatorPere Joan Cardona
dc.creatorSusana Roque
dc.creatorPerpetua Pinto do O
dc.creatorRui Appelberg
dc.creatorMargarida Correia Neves
dc.date.accessioned2019-01-31T22:00:40Z-
dc.date.available2019-01-31T22:00:40Z-
dc.date.issued2007
dc.identifier.issn1286-4579
dc.identifier.othersigarra:88228
dc.identifier.urihttps://repositorio-aberto.up.pt/handle/10216/93472-
dc.description.abstractMycobacterial infections are among the major health threats worldwide. Ability to fight these infections depends on the host's immune response, particularly on macrophages and T lymphocytes produced by the thymus. Using the mouse as a model, and two different routes of infection (aerogenic or intravenous), we show that the thymus is consistently colonized by Mycobacterium tuberculosis, Mycobacterium avium or Mycobacterium bovis BCG. When compared to organs such as the liver and spleen, the bacterial load reaches a plateau at later time-points after infection. Moreover, in contrast with organs such as the spleen and the lung no granuloma were found in the thymus of mice infected with M. tuberculosis or M. avium. Since T cell differentiation depends, to a large extent, on the antigens encountered within the thymus, infection of this organ might alter the host's immune response to infection. Therefore, from now on, the thymus should be considered in studies addressing the immune response to mycobacterial infection.
dc.language.isoeng
dc.rightsrestrictedAccess
dc.subjectImunologia, Medicina básica
dc.subjectImmunology, Basic medicine
dc.titleThe thymus as a target for mycobacterial infections
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoInstituto de Ciências Biomédicas Abel Salazar
dc.identifier.doi10.1016/j.micinf.2007.08.006
dc.identifier.authenticusP-004-6M3
dc.subject.fosCiências médicas e da saúde::Medicina básica
dc.subject.fosMedical and Health sciences::Basic medicine
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

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