Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/91692
Author(s): | Gomes, MS Appelberg, R |
Title: | NRAMP1-or cytokine-induced bacteriostasis of Mycobacterium avium by mouse macrophages is independent of the respiratory burst |
Issue Date: | 2002 |
Abstract: | Restriction of the growth of Mycobacterium avium was studied in wild-type and p47(phox)-deficient macrophages. The ability of gamma interferon and tumour necrosis factor alpha to induce anti mycobacteria I activity in bone-marrow-derived macrophages or the expression of the NRAMP1-mediated resistance to M. avium were not affected by the deficiency in p47(phox). The addition of exogenous iron increased mycobacterial growth in macrophages expressing a functional NRAMP1 protein or a mutant NRAMP1 protein. Reactive oxygen species are therefore not involved in the constitutive or induced anti-M. avium activities of the mouse macrophage. |
Subject: | Infecções, Ciências biológicas Infections, Biological sciences |
Scientific areas: | Ciências exactas e naturais::Ciências biológicas Natural sciences::Biological sciences |
URI: | https://hdl.handle.net/10216/91692 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | restrictedAccess |
Appears in Collections: | ICBAS - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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88197.pdf Restricted Access | 329.71 kB | Adobe PDF | Request a copy from the Author(s) |
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