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Author(s): N. Eynon
J. A. Duarte
J. Oliveira
M Sagiv
C. Yamin
Y. Meckel
M. Sagiv
E. Goldhammer
Title: ACTN3 R577X Polymorphism and Israeli Top-level Athletes
Issue Date: 2009
Abstract: A common genetic variation in the alpha-actinin-3 (ACTN3) gene causes a replacement of an arginine (R) with a premature stop codon (X) at amino-acid 577 (rs1815739). While the R allele has been found to be associated with power-oriented performance, the XX genotype may be linked with endurance ability. To test this hypothesis, we studied the distribution of ACTN3 genotypes in 155 Israeli athletes (age = 35.9 + 12.2 years) classified by sport (endurance runners and sprinters) and in 240 sedentary individuals. The sprinters' allele frequencies (AF: R/X = 0.7/0.3) and 577RR genotype distribution percentage (GD: RR = 52%) differed markedly from those of the endurance athletes (AF: R/X = 0.53/0.47, p = 0.000007; GD: RR = 18%, p = 0.00009) and the control group (AF: R/X = 0.55/0.45, p = 0.0002; GD: RR = 27.3%, p = 0.000003). A comparison between the top-level and national-level sprinters revealed that the R allele occurs more often in the top-level sprinters. A significantly higher proportion of the XX genotype was observed in endurance athletes (34%) compared with controls (18%, p = 0.02) and sprinters (13%, p = 0.002). However, top-level and national level endurance athletes had similar allele and genotype frequencies. We conclude that the ACTN3 R allele is associated with top-level sprint performance and the X allele and XX genotypes may not be critical but rather additive to endurance performance.
Subject: Ciências da saúde
Health sciences
Scientific areas: Ciências médicas e da saúde::Ciências da saúde
Medical and Health sciences::Health sciences
Document Type: Artigo em Revista Científica Internacional
Rights: restrictedAccess
Appears in Collections:FADEUP - Artigo em Revista Científica Internacional

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