Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/69097
Author(s): Florido, M
Appelberg, R
Title: Granuloma necrosis during Mycobacterium avium infection does not require tumor necrosis factor
Issue Date: 2004
Abstract: The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon responses as evaluated in the sera of infected animals, and showed reduced survival. Thus, TNF is not required for granuloma necrosis.
Subject: Infecções, Medicina básica
Infections, Basic medicine
Scientific areas: Ciências médicas e da saúde::Medicina básica
Medical and Health sciences::Basic medicine
URI: https://repositorio-aberto.up.pt/handle/10216/69097
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by-nc/4.0/
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

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