Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/64509
Author(s): Varga, Orsolya E
Hansen, Axel K
Sandøe, P
Olsson, I Anna S
Title: Validating animal models for preclinical research: a scientific and ethical discussion
Publisher: Fund for the Replacement of Animals in Medical Experiments
Issue Date: 2010
Abstract: The use of animals to model humans in biomedical research relies on the notion that basic processes are sufficiently similar across species to allow extrapolation. Animal model validity is discussed in terms of the similarity between the model and human condition it is intended to model, but no formal validation of models is applied. There is a stark contrast here with non-animal alternatives in toxicology and safety studies, for which an extensive validation is required. In the present paper we discuss the potential and limitations of validating preclinical animal models for proof-of-concept studies using an approach similar to that applied to alternative non-animal methods in toxicology and safety testing. A major challenge in devising a validation system for animal models is the lack of a clear gold standard to compare results with. While a complete adoption of the validation approach for alternative methods is probably inappropriate for research animal models, key feature such as making data available for external validation and defining a strategy to run experiments in a way that permits meaningful retrospective analysis remain relevant.
Subject: Animal models
Predictive validity
Validation
Ethics
URI: http://hdl.handle.net/10216/64509
Catalogue Link: http://www.frame.org.uk/atla_article.php?art_id=1281&abstract=true
Source: Alternatives to laboratory animals : ATLA, vol.38(3), p.245-248
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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