Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/53789
Author(s): Maiato, H
Lince-Faria, Mariana
Title: The perpetual movements of anaphase
Alternative title: Anaphase chromosome movements
Issue Date: 2010
Abstract: One of the most extraordinary events in the lifetime of a cell is the coordinated separation of sister chromatids during cell division. This is truly the essence of the entire mitotic process and the reason for the most profound morphological changes in cytoskeleton and nuclear organization that a cell may ever experience. It all occurs within a very short time window known as “anaphase”, as if the cell had spent the rest of its existence getting ready for this moment in an ultimate act of survival. And there is a good reason for this: no space for mistakes. Problems in the distribution of chromosomes during cell division have been correlated with aneuploidy, a common feature observed in cancers and several birth defects, and the main cause of spontaneous abortion in humans. In this paper we critically review the mechanisms of anaphase chromosome motion that resisted the scrutiny of more than one hundred years of research as part of a tribute to the pioneering work of Miguel Mota.
Subject: Pac-man
Flux
Dynein
Anaphase
Force
URI: http://hdl.handle.net/10216/53789
Catalogue Link: http://dx.doi.org/10.1007/s00018-010-0327-5
Source: Cellular and Molecular Life Sciences, vol. 67(13), P.2251-2269
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
The Perpetual Movements of Anaphase.pdf1.93 MBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.