Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

Self-assembled monolayers (SAMs) represent highly ordered molecular materials with versatile biochemical features and multidisciplinary applications. Research on SAMs has made much progress since the early begginings of Au substrates and alkanethiols, and numerous examples of peptide-displaying SAMs can be found in the literature. Peptides, presenting increasing structural complexity, stimuli-responsiveness, and biological relevance, represent versatile functional components in SAMs-based pla...

Exploring innovative adhesive approaches to manage medical adhesive-related skin injuries (MARSI)

Medical adhesives are essential to secure wound care dressings and medical devices to the skin, to bind wound edges, track vital signs, or even provide local drug delivery. Despite several options in the market, most medical adhesives are composed of acrylate, hydrocolloid, and silicone, materials that are associated with the development of Medical Adhesive-Related Skin Injury (MARSI). Moreover, these injuries reduce skin integrity, causing pain, delaying wound healing, and increasing the ris...

Paving the way for a non‐antibiotic and microbiota friendly therapy for Helicobacter pylori: In vitro and in vivo performance of lipid nanoparticles

Background: The World Health Organization has identified Helicobacter pylori, a Gram-negative bacterium responsible for several gastric disorders, as one of the pathogenic bacteria that requires newer non-antibiotic approaches for its management. We previously demonstrated that nanostructured lipid carriers (NLC) loaded with docosahexaenoic acid (DHA-NLC)have excellent in vitro performance against H. pylori. Materials and Methods: NLC were tested against different H. pylori strains and bac...

Norbornene-chitosan nanoparticles with and without a conjugated VEGF-peptide analog to promote vascularization

Impaired angiogenesis in skin chronic wounds prolongs inflammation and compromises wound healing. Several strategies have been attempted to improve vascularization, such as application of growth factors, like the vascular endothelial growth factor (VEGF). However, VEGF is expensive, has a short half-life in vivo and has been associated to tumorigenesis when used in high concentrations. QK peptide is a shorter (15 amino acids), synthetic, VEGF-mimetic peptide with improved stability and lower ...