Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

Abstract

The drug-coated balloons (DCBs) provide a combination therapy of balloon angioplasty and anti-proliferative drug delivery totarget lesions, thereby facilitating the appealing concept of leaving nothing behind. However, several studies have highlightedsignificant challenges posed by low drug transfer efficiency and immediate lumen loss due to elastic recoil. Herein, we propose abioabsorbable endovascular adhesive tape (BEAT) platform that can realize robust adhesion and complete transfer after ballooninflation, enabling efficient endoluminal drug delivery while providing temporary radial support against elastic recoil. ThisBEAT coated balloon contains sprayable Janus coating layers of crosslinked drug-eluting polyelectrolyte complexes (PECs) andpoly(thioctic acid) (PTA) adhesive layer. Notably, the poly (L-lysine-co-L-leucine)-poly (acrylic acid) PECs (PKL-PAA, KLA) exhibitexceptional anti-coagulation properties and selective endothelial cell adhesion behavior. Moreover, the hydrophobic interactionand photo-controllable crosslinking of KLA PECs enable flexible mechanical tunability (0.74–10.9 MPa), robust swelling resistance,and enzyme-responsive biodegradability, thus guaranteeing temporary mechanical reinforcement for blood vessels with efficientdrug delivery. In a rat abdominal aorta injury model, this BEAT coated balloon demonstrates intact transfer with mechanicalcompliance to the vessel and effectively attenuates neointimal hyperplasia. This BEAT platform offers a promising perspective forthe development of DCBs in vascular interventions.