Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/152433
Author(s): Barroso, C
Carvalho, P
Gonçalves, JFM
Rodrigues, P
Neves, JV
Title: Antimicrobial peptides: Identification of two beta-defensins in a teleost fish, the european sea bass (dicentrarchus labrax)
Publisher: MDPI
Issue Date: 2021
Abstract: Beta-defensins consist in a group of cysteine-rich antimicrobial peptides (AMPs), widely found throughout vertebrate species, including teleost fish, with antimicrobial and immunomodulatory activities. However, although the European sea bass (Dicentrarchus labrax) is one of the most commercially important farmed fish species in the Mediterranean area, the characterization of its beta-defensins and its potential applications are still missing. In this study, we characterized two members of the beta-defensin family in this species. Phylogenetic and synteny analysis places sea bass peptides in the beta-defensin subfamilies 1 and 2, sharing similar features with the other members, including the six cysteines and the tertiary structure, that consists in three antiparallel beta-sheets, with beta-defensin 1 presenting an extra alpha-helix at the N-terminal. Further studies are necessary to uncover the functions of sea bass beta-defensins, particularly their antimicrobial and immunomodulatory properties, in order to develop novel prophylactic or therapeutic compounds to be used in aquaculture production.
Subject: Antimicrobial peptides
Aquaculture
Betadefensins
European sea bass (Dicentrarchus labrax)
URI: https://hdl.handle.net/10216/152433
Source: Pharmaceuticals, vol.14(6):566
Related Information: info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F114899%2F2016/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:I3S - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
10.3390-ph14060566.pdf9.24 MBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons