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Author(s): Borges-Canha, M
Neves, JS
Mendonça, F
Silva, MM
Costa, C
Cabral, PM
Guerreiro, V
Lourenço, R
Meira, P
Salazar, D
Ferreira, MJ
Pedro, J
Leite, AR
Von-Hafe, M
Vale, C
Viana, S
Varela, A
Belo, S
Lau, E
Freitas, P
Carvalho, D
Title: The impact of vitamin d in non-alcoholic fatty liver disease: A cross-sectional study in patients with morbid obesity
Publisher: Dove Medical Press
Issue Date: 2021
Abstract: Purpose: We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods: Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. Patients with missing vitamin D levels or hepatic profile parameters were excluded. We divided the population according to two cut-offs of vitamin D levels (12ng/mL and 20ng/mL). Results: The included population (n=1124) had an average age of 43.3±10.7 years and 84.3% were female. Seventy-point eight percent of the population had vitamin D levels lower than 20ng/mL and 34.8% lower than 12ng/dL. Patients with lower vitamin D levels (<12ng/mL) had higher BMI, hip and waist circumferences and higher prevalence of hypertension. Higher FLI scores [OR= 0.77 (0.07), p<0.01] and ALP levels [ß= -0.03 (-0.06, -0.01), p<0.01] associated to lower vitamin D levels. Conclusion: Vitamin D deficiency is associated with a higher risk of hepatic steatosis in individuals with morbid obesity. Correction of vitamin D deficiency may have a beneficial role in the management of NAFLD in patients with morbid obesity.
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol.14, p. 487-495
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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