Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/145264
Author(s): Sharifi-Rad, M
Lankatillake, C
Dias, DA
Docea, AO
Mahomoodally, MF
Lobine, D
Chazot, PL
Kurt, B
Tumer, TB
Moreira, AC
Sharopov, F
Martorell, M
Martins, N
Cho, WC
Calina, D
Sharifi-Rad, J
Title: Impact of natural compounds on neurodegenerative disorders: From preclinical to pharmacotherapeutics
Publisher: MDPI
Issue Date: 2020
Abstract: Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article review the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.
Subject: Alzheimer’s disease
Dementias
Natural compounds
Neurodegenerative disorders
Parkinson’s disease
Pharmacological activities
Plants secondary metabolites
URI: https://hdl.handle.net/10216/145264
Source: Journal of Clinical Medicine, vol.9(4):1061
Related Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04293%2F2013/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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