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Author(s): Catarata, MJ
Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
Title: Renin-angiotensin system in lung tumor and microenvironment interactions
Publisher: MDPI
Issue Date: 2020
Abstract: The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
Subject: Hypoxia
Lung cancer
Tumor microenvironment
Source: Cancers, vol.12(6):1457
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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