Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/143123
Author(s): | Lobato, CB Pereira, SS Guimarães, M Morais, T Oliveira, P de Carvalho, JPM Nora, M Monteiro, MP |
Title: | Use of flash glucose monitoring for post-bariatric hypoglycaemia diagnosis and management |
Publisher: | Nature Research |
Issue Date: | 2020 |
Abstract: | Our aim was to assess the potential of flash glucose monitoring (FGM) for diagnostic workup of suspected post-bariatric hypoglycaemia (PBH). Patients (N = 13) with suspected PBH underwent a food and symptoms diary (FSD) record along with FGM over 14 days. Targeted data analysis confirmed the occurrence of low glucose events in parallel to meal-triggered symptoms. Glycaemic variability, as assessed by Mean Absolute Glucose change (MAG change), was increased, while a higher risk of glycaemic excursions towards both hyper and hypoglycaemia (ADRRFGMGT) was observed in those with more frequent and severe hypoglycaemia. The herein described hypoglycaemia risk index (LBGIFGMGT) with a cut-off value of 4.6 showed to have 100% sensitivity and 100% specificity for PBH. This pilot proof-of-concept study highlighted that FSD coupled with FGM followed by targeted data analysis, provides relevant insights towards PBH diagnosis and grading in a user-friendly and easy to implement study protocol. Furthermore, LBGIFGMGT demonstrated to be an excellent index for PBH diagnosis. The unexpected improvement of glucose profile noticed along the monitoring time also unravels a possible application for PBH management. |
URI: | https://hdl.handle.net/10216/143123 |
Source: | Sci Rep. 2020 Jul 6;10(1):1106 |
Related Information: | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/MULTI/0215/2016/PT info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/00215/2020/PT info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP/00215/2020/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | ISPUP - Artigo em Revista Científica Internacional |
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File | Description | Size | Format | |
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lobato-sr-2020.pdf | 2.28 MB | Adobe PDF | View/Open |
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