Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/142516
Author(s): Corso, G
Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
Title: E-cadherin deregulation in breast cancer
Publisher: Wiley
Issue Date: 2020
Abstract: E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
URI: https://hdl.handle.net/10216/142516
Source: Journal of Cellular and Molecular Medicine, vol.24(11), p. 5930-5936
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
10.1111-jcmm.15140.pdf708.51 kBAdobe PDFThumbnail
View/Open


This item is licensed under a Creative Commons License Creative Commons