Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/142516| Author(s): | Corso, G Figueiredo, J Angelis, SP Corso, F Girardi, A Pereira, J Seruca, R Bonanni, B Carneiro, P Pravettoni, G Guerini Rocco, E Veronesi, P Montagna, G Sacchini, V Gandini, S |
| Title: | E-cadherin deregulation in breast cancer |
| Publisher: | Wiley |
| Issue Date: | 2020 |
| Abstract: | E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy. |
| DOI: | 10.1111/jcmm.15140 |
| URI: | https://hdl.handle.net/10216/142516 |
| Source: | Journal of Cellular and Molecular Medicine, vol.24(11), p. 5930-5936 |
| Document Type: | Artigo em Revista Científica Internacional |
| Rights: | openAccess |
| License: | https://creativecommons.org/licenses/by/4.0/ |
| Appears in Collections: | ICBAS - Artigo em Revista Científica Internacional |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 10.1111-jcmm.15140.pdf | 708.51 kB | Adobe PDF |  View/Open |
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