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Author(s): Corso, G
Figueiredo, J
Angelis, SP
Corso, F
Girardi, A
Pereira, J
Seruca, R
Bonanni, B
Carneiro, P
Pravettoni, G
Guerini Rocco, E
Veronesi, P
Montagna, G
Sacchini, V
Gandini, S
Title: E-cadherin deregulation in breast cancer
Publisher: Wiley
Issue Date: 2020
Abstract: E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
Source: Journal of Cellular and Molecular Medicine, vol.24(11), p. 5930-5936
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:ICBAS - Artigo em Revista Científica Internacional

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