Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/141477
Author(s): | Neves, MI Araújo, M Moroni, L Silva, RMP Barrias, CC |
Title: | Glycosaminoglycan-inspired biomaterials for the development of bioactive hydrogel networks |
Publisher: | MDPI |
Issue Date: | 2020 |
Abstract: | Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented. |
URI: | https://hdl.handle.net/10216/141477 |
Source: | Molecules, vol.25(4):978 |
Related Information: | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F129855%2F2017/PT info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FCTM-COM%2F32431%2F2017/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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10.3390-molecules25040978.pdf | 5.74 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License