Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/136302
Author(s): | Silva, AF Faria-Costa, G Sousa-Nunes, F Santos, MF Ferreira-Pinto, MJ Duarte, D Rodrigues, I Guimarães, JT Leite-Moreira, A Moreira-Gonçalves, D Henriques-Coelho, T Negrão, R |
Title: | Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hypertension mediated by ERK and AKT inhibition |
Publisher: | MDPI |
Issue Date: | 2019 |
Abstract: | Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to modulate the pathophysiology of experimental PAH. Male Wistar rats with monocrotaline (MCT)-induced PAH (60 mg/kg) were allowed to drink either xanthohumol-fortified beer (MCT + FB) or 5.2% ethanol (MCT + SHAM) for a period 4 weeks. At the end of the protocol, cardiopulmonary exercise testing and hemodynamic recordings were performed, followed by sample collection for further analysis. FB intake resulted in a significant attenuation of the pulmonary vascular remodeling in MCT + FB animals. This improvement was paralleled with the downregulation in expression of proteins responsible for proliferation (ERK1/2), cell viability (AKT), and apoptosis (BCL-XL). Moreover, MCT + FB animals presented improved right ventricle (RV) function and remodeling accompanied by VEGFR-2 pathway downregulation. The present study demonstrates that a regular consumption of xanthohumol through FB modulates major remodeling pathways activated in experimental PAH. |
Subject: | Beer Monocrotaline Polyphenol Pulmonary arterial hypertension Remodeling Xanthohumol |
URI: | https://hdl.handle.net/10216/136302 |
Source: | Nutrients, vol.11(3):583 |
Related Information: | info:eu-repo/grantAgreement/FCT/5876/136105/PT info:eu-repo/grantAgreement/FCT/5876/147342/PT info:eu-repo/grantAgreement/FCT/5876/147335/PT info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F90010%2F2012/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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10.3390-nu11030583.pdf | 3.1 MB | Adobe PDF | View/Open |
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