Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/136283
Author(s): Long, S
Resende, D
Kijjoa, A
Silva, A
Fernandes, R
Xavier, CPR
Vasconcelos, MH
Sousa, E
Pinto, M
Title: Synthesis of new proteomimetic quinazolinone alkaloids and evaluation of their neuroprotective and antitumor effects
Publisher: MDPI
Issue Date: 2019
Abstract: New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (3) and fumiquinazoline G (1), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the anti analogs via a one-pot method, and the syn analogs by the Mazurkiewicz-Ganesan approach. The neuroprotection capacity of these compounds on the rotenone-damage human neuroblastoma cell SH-SY5y was evaluated using the MTT assay. Compounds 1, 3, 5, and 7 showed more than 25% protection. The antitumor activity was investigated using the sulforhodamine B assay and some compounds were tested on the non-malignant MCF-12A cells. Fumiquinazoline G (1) was the most potent compound, with GI50 values lower than 20 µM. Compounds 5, 7, and 11 were more active in all tumor cell lines when compared to their enantiomers. Compounds 5, 7, 10, and 11 had very little effect in the viability of the non-malignant cells. Differences between enantiomeric pairs were also noted as being essential for these activities the S-configuration at C-4. These results reinforce the previously described activities of the fiscalin B (3) as substance P inhibitor and fumiquinazoline G (1) as antitumor agent showing potential as lead compounds for the development of drugs for treatment of neurodegenerative disorders and cancer, respectively.
Subject: Antitumor
Enantioselectivity
Fiscalin B
Fumiquinazoline
Neuroprotection
Quinazolinones
URI: https://hdl.handle.net/10216/136283
Source: Molecules, vol.24(3):534
Related Information: info:eu-repo/grantAgreement/FCT/5876/147268/PT
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
License: https://creativecommons.org/licenses/by/4.0/
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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