1. Repositório Aberto da Universidade do Porto
  2. I3S - Instituto de Investigação e Inovação em Saúde
  3. I3S - Artigo em Revista Científica Internacional
Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/136270
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dc.creatorSilva, S
dc.creatorAlmeida, A
dc.creatorVale, N
dc.date.accessioned2021-09-20T10:52:33Z-
dc.date.available2021-09-20T10:52:33Z-
dc.date.issued2019
dc.identifier.issn2218-273X
dc.identifier.urihttps://hdl.handle.net/10216/136270-
dc.description.abstractCell-penetrating peptides (CPPs), also known as protein translocation domains, membrane translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid residues capable of penetrating biological barriers and cellular membranes. Furthermore, CPP have become an alternative strategy to overcome some of the current drug limitations and combat resistant strains since CPPs are capable of delivering different therapeutic molecules against a wide range of diseases. In this review, we address the recent conjugation of CPPs with nanoparticles, which constitutes a new class of delivery vectors with high pharmaceutical potential in a variety of diseases.
dc.description.sponsorshipThis work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia, in the framework of the projects “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274) and iMed.ULisboa (UID/DTP/04138/2013). NV also acknowledges support from FCT and FEDER (European Union), award number IF/00092/2014/CP1255/CT0004. Acknowledgments: N.V. thanks F.C.T. for the IF position and Fundação Manuel António da Mota (F.M.A.M., Porto, Portugal) and Pfizer (Portugal) for support for the Nuno Vale Research Group. SS thanks FCT for her PhD Grant (PD/BD/135456/2017) and PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) from the University of Lisbon (Portugal) and the University of Porto (Portugal) for all support. The contents of this Review are solely the responsibility of the authors and do not necessarily represent the official views of the F.C.T.,F.M.A.M. and Pfizer.
dc.language.isoeng
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147348/PT
dc.relation.ispartofBiomolecules, vol.9(1):22
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCell-penetrating peptides
dc.subjectDelivery systems
dc.subjectMembrane translocation
dc.subjectNanoparticles
dc.subjectTherapeutic molecule
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents / chemistry
dc.subject.meshAntineoplastic Agents / metabolism
dc.subject.meshAntineoplastic Agents / therapeutic use
dc.subject.meshBlood-Brain Barrier / metabolism
dc.subject.meshCell-Penetrating Peptides / chemistry
dc.subject.meshCell-Penetrating Peptides / metabolism
dc.subject.meshCentral Nervous System Diseases / drug therapy
dc.subject.meshCentral Nervous System Diseases / pathology
dc.subject.meshHumans
dc.subject.meshMicroRNAs / chemistry
dc.subject.meshMicroRNAs / metabolism
dc.subject.meshNanoparticles / chemistry
dc.subject.meshNanoparticles / therapeutic use
dc.subject.meshNeoplasms / drug therapy
dc.subject.meshNeoplasms / pathology
dc.subject.meshPolymers / chemistry
dc.titleCombination of cell-penetrating peptides with nanoparticles for therapeutic application: A review
dc.typeArtigo em Revista Científica Internacional
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde
dc.identifier.doi10.3390/biom9010022
dc.relation.publisherversionhttps://www.mdpi.com/2218-273X/9/1/22
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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