Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/130455
Author(s): Pereira, F.
Almeida, J.R.
Paulino, M.
Grilo, I.R.
Macedo, H.
Cunha, I.
Sobral, R.G.
Vasconcelos, V.
Gaudêncio, S.P.
Title: Antifouling napyradiomycins from marine-derived actinomycetes streptomyces aculeolatus
Publisher: MDPI
Issue Date: 2020
Abstract: The undesired attachment of micro and macroorganisms on water-immersed surfaces, known as marine biofouling, results in severe prevention and maintenance costs (billions €/year) for aquaculture, shipping and other industries that rely on coastal and off-shore infrastructures. To date, there are no sustainable, cost-effective and environmentally safe solutions to address this challenging phenomenon. Therefore, we investigated the antifouling activity of napyradiomycin derivatives that were isolated from actinomycetes from ocean sediments collected off the Madeira Archipelago. Our results revealed that napyradiomycins inhibited ≥80% of the marine biofilm-forming bacteria assayed, as well as the settlement of Mytilus galloprovincialis larvae (EC50 < 5 µg/ml and LC50/EC50 >15), without viability impairment. In silico prediction of toxicity end points are of the same order of magnitude of standard approved drugs and biocides. Altogether, napyradiomycins disclosed bioactivity against marine micro and macrofouling organisms, and non-toxic effects towards the studied species, displaying potential to be used in the development of antifouling products.
Subject: Actinomycetes
Antibiofilm
Antifouling
Biofouling
Bioprospection
Drug discovery
Hybrid isoprenoids
Marine natural products
Meroterpenoids
Napyradiomycins
URI: https://hdl.handle.net/10216/130455
Source: Marine Drugs 2020, 18(1), 63
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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