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Author(s): Martins, T.P.
Rouger, C
Glasser, N.R
Freitas, S
De Fraissinette, N.B
Balskus, E.P
Tasdemir, D
Leão, P.N.
Title: Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols
Publisher: Natural Products Reports
Issue Date: 2019
Abstract: Covering: up to 2019 Alkylresorcinols are amphiphilic metabolites, well-known for their diverse biological activities, produced by both prokaryotes and eukaryotes. A few classes of alkylresorcinol scaffolds have been reported from the photoautotrophic cyanobacteria, ranging from the relatively simple hierridins to the more intricate cylindrocyclophanes. Recently, it has emerged that cyanobacteria employ two different biosynthetic pathways to produce unique alkylresorcinol scaffolds. However, these convergent pathways intersect by sharing biosynthetic elements which lead to common structural motifs. To obtain a broader view of the biochemical diversity of these compounds in cyanobacteria, we comprehensively cover the isolation, structure, biological activity and biosynthesis of their mono- and dialkylresorcinols. Moreover, we provide an overview of the diversity and distribution of alkylresorcinol-generating biosynthetic gene clusters in this phylum and highlight opportunities for discovery of novel alkylresorcinol scaffolds. Because some of these molecules have inspired notable syntheses, different approaches used to build these molecules in the laboratory are showcased. © The Royal Society of Chemistry.
Subject: resorcinol derivative
chemical structure
multigene family
Molecular Structure
Multigene Family
Source: Nat. Prod. Rep., 2019, 36, 1437
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:CIIMAR - Artigo em Revista Científica Internacional

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