Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/127646
Author(s): Soraia Neves
Ponmozhi Jeyaraj
Campos, JBLM
Miranda, JM
Title: Biofouling in microdevices: a numerical study with OpenFOAM
Issue Date: 2019-06-12
Abstract: Biofouling in microstructures has been responsible for severe infections in body regions like eyes (by contact lenses usage), kidney and bladder (catheter-associated urinary tract infections). Despite the strong impact in the subject health, there is a lack of knowledge about the biofouling formation at microscale. For that reason, a comprehensive understanding of the initial stages of fouling formation such as initial cell adhesion could lead to new and improved engineering solutions. In this work, experimental and numerical tests of cell adhesion were carried out mimicking the in vivo body temperature and focus was put in the adhesion of cells in the bottom walls of a micro device (Fig. 1). The experimental tests considered a diluted E. coli suspension [1]. Moreover, the cell adhesion was studied for a range of operating conditions characteristic of biomedical devices. The numerical studies followed a Eulerian-Lagrangian approach ('icoUncoupledKinematicParcelFoam' solver), assumed the particles equivalent to cells and considered a one-way coupling schemes between the particles and the fluid flow [2]. Furthermore, a new particle-surface interaction and lift force were added to the existing solver. Open Source software were used in all the design procedure steps (e.g. OpenScad and R). The numerical approach predicted well the cell adhesion rate for low shear rates (lower than 0.03 Pa). Promising results have been obtained for the highest values of shear rates.
URI: https://hdl.handle.net/10216/127646
Source: 3rd Iberian Meeting of OpenFOAM® Technology Users
Related Information: info:eu-repo/grantAgreement/FCT - Fundação para a Ciência e a Tecnologia/P2020|COMPETE - Projetos em Todos os Domínios Científicos/PTDC/QEQ-FTT/4287/2014 - POCI-01-0145-FEDER-016861/Novos fluidos biomiméticos para aplicações biomédicas/PTDC/QEQ-FTT/4287/2014|16861
Document Type: Resumo de Comunicação em Conferência Internacional
Rights: openAccess
Appears in Collections:FEUP - Resumo de Comunicação em Conferência Internacional

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