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dc.creatorAlejo, A-
dc.creatorRuiz-Argüello, M-
dc.creatorPontejo, S-
dc.creatorFernández De Marco, M-
dc.creatorSaraiva, M-
dc.creatorHernáez, B-
dc.creatorAlcamí, A-
dc.description.abstractThe role of cytokines and chemokines in anti-viral defense has been demonstrated, but their relative contribution to protective anti-viral responses in vivo is not fully understood. Cytokine response modifier D (CrmD) is a secreted receptor for TNF and lymphotoxin containing the smallpox virus-encoded chemokine receptor (SECRET) domain and is expressed by ectromelia virus, the causative agent of the smallpox-like disease mousepox. Here we show that CrmD is an essential virulence factor that controls natural killer cell activation and allows progression of fatal mousepox, and demonstrate that both SECRET and TNF binding domains are required for full CrmD activity. Vaccination with recombinant CrmD protects animals from lethal mousepox. These results indicate that a specific set of chemokines enhance the inflammatory and protective anti-viral responses mediated by TNF and lymphotoxin, and illustrate how viruses optimize anti-TNF strategies with the addition of a chemokine binding domain as soluble decoy receptors.-
dc.description.sponsorshipWe thank Javier Salguero for help with animal experimentation and immunohistochemistry, Rocío Martín and Carolina Sánchez for technical assistance and Daniel Rubio for discussions on the project. This work was funded by Grants from the Spanish Ministry of Economy and Competitiviness and European Union (European Regional Development’s Funds, FEDER) (grant SAF2015-67485-R), and the Wellcome Trust (grant 051087/Z97/Z). M.B.R.-A. and A. Alejo were recipients of a Ramón y Cajal Contract from the Spanish Ministry of Science and Innovation.-
dc.relation.ispartofNature Communications, vol.9(1):1790-
dc.subject.meshCD8-Positive T-Lymphocytes / immunology-
dc.subject.meshCell Line-
dc.subject.meshChemokines / physiology-
dc.subject.meshEctromelia, Infectious / immunology-
dc.subject.meshEctromelia, Infectious / prevention & control-
dc.subject.meshInflammation / etiology-
dc.subject.meshInflammation / immunology-
dc.subject.meshKiller Cells, Natural / immunology-
dc.subject.meshMice, Inbred BALB C-
dc.subject.meshPoxviridae / pathogenicity-
dc.subject.meshTumor Necrosis Factor-alpha / physiology-
dc.subject.meshVirulence Factors / physiology-
dc.subject.meshVirus Replication-
dc.titleChemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation-
dc.typeArtigo em Revista Científica Internacional-
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde-
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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