Please use this identifier to cite or link to this item: https://hdl.handle.net/10216/126620
Author(s): Leite, DM
Sousa, DM
Lamghari, M
Pêgo, AP
Title: Exploring Poly(Ethylene Glycol)-Poly(Trimethylene Carbonate) Nanoparticles as Carriers of Hydrophobic Drugs to Modulate Osteoblastic Activity
Publisher: Elsevier
Issue Date: 2020-01-11
Abstract: Current treatment options for bone-related disorders rely on a systemic administration of therapeutic agents that possess low solubility and intracellular bioavailability, as well as a high pharmacokinetic variability, which in turn lead to major off-target side effects. Hence, there is an unmet need of developing drug delivery systems that can improve the clinical efficacy of such therapeutic agents. Nanoparticle delivery systems might serve as promising carriers of hydrophobic molecules. Here, we propose 2 nanoparticle-based delivery systems based on monomethoxy poly(ethylene glycol)-poly(trimethyl carbonate) (mPEG-PTMC) and poly(lactide-co-glycolide) for the intracellular controlled release of a small hydrophobic drug (dexamethasone) to osteoblast cells in vitro. mPEG-PTMC self-assembles into stable nanoparticles in the absence of surfactant and shows a greater entrapment capacity of dexamethasone, while assuring bioactivity in MC3T3-E1 and bone marrow stromal cells cultured under apoptotic and osteogenic conditions, respectively. The mPEG-PTMC nanoparticles represent a potential vector for the intracellular delivery of hydrophobic drugs in the framework of bone-related diseases.
Subject: Biodegradable polymers
Nanomedicine
Nanoparticles
Polyglycolic acid (PLGA)
Polymeric drug delivery systems
Poorly water-soluble drug
URI: https://hdl.handle.net/10216/126620
Series: Journal of pharmaceutical sciences
Related Information: info:eu-repo/grantAgreement/FCT/COMPETE/132934/PT|| info:eu-repo/grantAgreement/FCT/COMPETE/125869/PT
Document Type: Artigo em Revista Científica Internacional
Rights: embargoedAccess
Embargo End Date: 2021-01-11
Appears in Collections:I3S - Artigo em Revista Científica Internacional

Files in This Item:
File Description SizeFormat 
10.1016-j.xphs.2020.01.007.pdf
  Until 2021-01-11
1.01 MBAdobe PDF    Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.