Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/126500
Author(s): | Castro, F Cardoso, AP Gonçalves, RM Serre, K Oliveira, MJ |
Title: | Interferon-gamma at the crossroads of tumor immune surveillance or evasion |
Publisher: | Frontiers Media |
Issue Date: | 2018 |
Abstract: | Interferon-gamma (IFN-¿) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN-¿ in tumor immune surveillance, IFN-¿-based therapies undergoing clinical trials have been of limited success. In fact, recent reports suggested that it may also play a protumorigenic role, namely, through IFN-¿ signaling insensitivity, downregulation of major histocompatibility complexes, and upregulation of indoleamine 2,3-dioxygenase and of checkpoint inhibitors, as programmed cell-death ligand 1. However, the IFN-¿-mediated responses are still positively associated with patient's survival in several cancers. Consequently, major research efforts are required to understand the immune contexture in which IFN-¿ induces its intricate and highly regulated effects in the tumor microenvironment. This review discusses the current knowledge on the pro- and antitumorigenic effects of IFN-¿ as part of the complex immune response to cancer, highlighting the relevance to identify IFN-¿ responsive patients for the improvement of therapies that exploit associated signaling pathways. |
Subject: | Cancer microenvironment Immune contexture Immunoregulation Immunotherapy Type II interferon |
URI: | https://hdl.handle.net/10216/126500 |
Source: | Frontiers in Immunology, vol.9:847 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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10.3389-fimmu.2018.00847.pdf | 1.2 MB | Adobe PDF | View/Open |
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