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dc.creatorCunha, C-
dc.creatorSilva, A-
dc.creatorPereira, P-
dc.creatorVaz, R-
dc.creatorGonçalves, RM-
dc.creatorBarbosa, MA-
dc.description.abstractLumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that may lead to pain. However, inflammation has also been indicated as the main factor responsible for LDH regression. This apparent controversy places inflammation as a good prognostic indicator of spontaneous regression of LDH. This review addresses the molecular and cellular mechanisms involved in LDH regression, including matrix remodeling and neovascularization, in the scope of the clinical decision on conservative versus surgical intervention. Based on the evidence, a special focus on the inflammatory response in the LDH context is given, particularly in the monocyte/macrophage role. The phenomenon of spontaneous regression of LDH, extensively reported in the literature, is therefore analyzed here under the perspective of the modulatory role of inflammation.-
dc.description.sponsorshipThis work was financed by project “Bioengineered Therapies for infectious diseases and tissue regeneration” (NORTE-01-0145-FEDER-000012), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), by FEDER/COMPETE 2020 (POCI), Portugal 2020, and by Portuguese funds through FCT/MCTES in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01- 0145-FEDER-007274). Cunha C and Gonçalves RM acknowledge FCT by their postdoc fellowship (SFRH/BDP/87071/2012) and FCT Investigator Grant (IF/ 00638/2014), respectively. Silva AJ acknowledges her fellowship under the framework of the project Norte-01-0145-FEDER-000012.-
dc.relation.ispartofArthritis Research and Therapy, vol.20(1), p. 251-
dc.subject.meshIntervertebral Disc Degeneration/diagnosticimaging-
dc.subject.meshIntervertebral Disc Degeneration/epidemiology-
dc.subject.meshIntervertebral Disc Degeneration/immunology-
dc.subject.meshIntervertebral Disc Displacement/diagnostic-
dc.subject.meshIntervertebral Disc Displacement/epidemiology-
dc.subject.meshIntervertebral Disc Displacement/immunology-
dc.subject.meshLow Back Pain/diagnostic imaging-
dc.subject.meshLow Back Pain/epidemiology-
dc.subject.meshLow Back Pain/immunology-
dc.subject.meshLumbar Vertebrae/diagnostic imaging-
dc.subject.meshLumbar Vertebrae/immunology-
dc.subject.meshRemission, Spontaneous-
dc.titleThe inflammatory response in the regression of lumbar disc herniation-
dc.typeArtigo em Revista Científica Internacional-
dc.contributor.uportoInstituto de Investigação e Inovação em Saúde-
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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