Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/126486
Author(s): | Azevedo, R Gaiteiro, C Peixoto, A Relvas-Santos, M Lima, L Santos, L Ferreira, JA |
Title: | CD44 glycoprotein in cancer: A molecular conundrum hampering clinical applications |
Publisher: | BMC |
Issue Date: | 2018 |
Abstract: | CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently explored for stem cell identification, and associated with chemoresistance and metastasis. However, CD44 is a general designation for a large family of splicing variants exhibiting different degrees of glycosylation and, potentially, functionally distinct roles. Moreover, structural diversity associated with ambiguous nomenclature has delayed clinical developments. Herein, we attempt to comprehensively address these aspects and systematize CD44 nomenclature, setting milestones for biomarker discovery. In addition, we support that CD44 may be an important source of cancer neoantigens, most likely resulting from altered splicing and/or glycosylation. The discovery of potentially targetable CD44 (glyco)isoforms will require the combination of glycomics with proteogenomics approaches, exploring customized protein sequence databases generated using genomics and transcriptomics. Nevertheless, the necessary high-throughput analytical and bioinformatics tools are now available to address CD44 role in health and disease. |
Subject: | Cancer biomarkers CD44 CD44 isoforms Glycosylation Nomenclature |
URI: | https://hdl.handle.net/10216/126486 |
Source: | Clinical Proteomics, vol.15:22 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/publicdomain/zero/1.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
Files in This Item:
File | Description | Size | Format | |
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10.1186-s12014-018-9198-9.pdf | 1.58 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License