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Author(s): Fonseca, KL
Rodrigues, PS
Olsson, IAS
Saraiva, M
Title: Experimental Study of Tuberculosis: From Animal Models to Complex Cell Systems and Organoids
Publisher: Public Library of Science
Issue Date: 2017
Abstract: Tuberculosis (TB) is a devastating disease to mankind that has killed more people than any other infectious disease. Despite many efforts and successes from the scientific and health communities, the prospect of TB elimination remains distant. On the one hand, sustainable public health programs with affordable and broad implementation of anti-TB measures are needed. On the other hand, achieving TB elimination requires critical advances in three areas: vaccination, diagnosis, and treatment. It is also well accepted that succeeding in advancing these areas requires a deeper knowledge of host-pathogen interactions during infection, and for that, better experimental models are needed. Here, we review the potential and limitations of different experimental approaches used in TB research, focusing on animal and human-based cell culture models. We highlight the most recent advances in developing in vitro 3D models and introduce the potential of lung organoids as a new tool to study Mycobacterium tuberculosis infection.
Description: We acknowledge financial support of the Humane Society International (HIS), Humane Society of the United States (HSUS), and from the Portuguese Foundation for Science and Technology (FCT) for providing a PhD grant to KLF (SFRH/BD/114405/2016). The MS lab is financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 -Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274). MS is a FCT Associate Investigator. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subject: Animals
Disease Models, Animal
Models, Biological
Series: PLoS pathogens, vol. 13(8):e1006421
Document Type: Artigo em Revista Científica Internacional
Rights: openAccess
Appears in Collections:I3S - Artigo em Revista Científica Internacional

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