Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/121101
Author(s): | Rocha DN Carvalho ED Pêgo AP |
Title: | High-throughput platforms for the screening of new therapeutic targets for neurodegenerative diseases |
Publisher: | Elsevier |
Issue Date: | 2016 |
Abstract: | Despite the recent progress in the understanding of neurodegenerative disorders, a lack of solid fundamental knowledge on the etiology of many of the major neurodegenerative diseases has made it difficult to obtain effective therapies to treat these conditions. Scientists have been looking to carry out more-human-relevant studies, with strong statistical power, to overcome the limitations of preclinical animal models that have contributed to the failure of numerous therapeutics in clinical trials. Here, we identify currently existing platforms to mimic central nervous system tissues, healthy and diseased, mainly focusing on cell-based platforms and discussing their strengths and limitations in the context of the high-throughput screening of new therapeutic targets and drugs. |
URI: | https://hdl.handle.net/10216/121101 |
Source: | Drug Discovery Today, vol.21(9), p. 1355-1366 |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
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