Please use this identifier to cite or link to this item:
https://hdl.handle.net/10216/120730
Author(s): | Moreno, PM Pêgo, AP |
Title: | Therapeutic antisense oligonucleotides against cancer: Hurdling to the clinic |
Publisher: | Frontiers Media |
Issue Date: | 2014 |
Abstract: | Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has not yet delivered a clinical drug to the market in the cancer field. Whilst many pre-clinical data has been generated, a lack of understanding still exists on how to efficiently tackle all the different challenges presented for cancer targeting in a clinical setting. Namely, effective drug vectorization, careful choice of target gene or synergistic multi-gene targeting are surely decisive, while caution must be exerted to avoid potential toxic, often misleading off-target-effects. Here a brief overview will be given on the nucleic acid chemistry advances that established oligonucleotide technologies as a promising therapeutic alternative and ongoing cancer related clinical trials. Special attention will be given toward a perspective on the hurdles encountered specifically in the cancer field by this class of therapeutic oligonucleotides and a view on possible avenues for success is presented, with particular focus on the contribution from nanotechnology to the field. |
Subject: | Antisense Cancer Nanomedicine Oligonucleotides Therapeutics |
URI: | https://hdl.handle.net/10216/120730 |
Source: | Frontiers in Chemistry, vol. 2:87 |
Related Information: | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115124/PT info:eu-repo/grantAgreement/FCT/5876-PPCDTI/116372/PT info:eu-repo/grantAgreement/FCT/COMPETE/132934/PT |
Document Type: | Artigo em Revista Científica Internacional |
Rights: | openAccess |
License: | https://creativecommons.org/licenses/by/4.0/ |
Appears in Collections: | I3S - Artigo em Revista Científica Internacional |
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